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Latest Updates of Viva Biotech's Portfolio Companies
Time: 2025-01-09
Source: Viva Biotech
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[Abstract]:Recently, 5 of Viva's portfolio companies have achieved significant results and progress.

Recently, Viva Biotech's portfolio companies have new updates: TechnoDerma, VivaVision, Arthrosi, Apeiron Therapeutics and AceLink made solid progress in R&D; Full Circles published breakthrough results; Antag successfully completed financing.


TechnoDerma Medicines Completes U.S. Positive Ph2a Proof-of-Concept Trial with TopicalTDM-180935 Ointment for Atopic Dermatitis


On 6 January 2025, TechnoDerma Medicines, Inc. ("TechnoDerma Medicines"), a clinical-stage biopharmaceutical company which is invested and incubated by Viva BioInnovator (VBI), reported that the Company has completed its Phase 2a clinical trial (NCT06363461) of topical TDM-180935 ointment in patients with Atopic Dermatitis (AD).


Results show that the treatment was well-tolerated and demonstrated strong efficacy. Only minimal systemic exposure was evident and, thus, will enable future application to large body surface areas often seen in AD. These positive results provide support for continued advancement of the Atopic Dermatitis program.


VivaVision's VVN461 Achieves Primary Endpoint in Phase II Clinical Trial for Non-infectious Anterior Uveitis in China and Reports Positive Topline Results from U.S. Phase 2 Trial for Post-Operative Inflammation Following Cataract Surgery


On January 3, 2025, VivaVision Biotech ("VivaVision"), invested and incubated by VBI, a clinical-stage, privately held biotechnology company focused on developing treatments for ocular diseases, announced that  VVN461 achieves clinical endpoints in Phase II clinical trial for non-infectious anterior uveitis.


VVN461 is a first-in-class non-steroidal dual  JAK1/TYK2 immunomodulator  independently developed by VivaVision. It demonstrated excellent anti-inflammatory effects in this clinical trial. Compared to the positive control prednisolone acetate 1% ophthalmic suspension , both dosage groups achieved statistical non-inferiority for both the both primary and secondary endpoints.


Previously, on December 3, 2024, VivaVision announced positive topline results from its U.S. Phase 2 clinical trial of VVN461-CS-201, a potent non-steroidal dual JAK1/TYK2 immunomodulator for the treatment of post-operative inflammation following cataract surgery. VVN461 demonstrated statistical and clinical improvements across primary and many secondary endpoints compared to vehicle.


Arthrosi Therapeutics Surpasses 50% Patient Enrollment in Pivotal Phase 3 REDUCE 2 Trial of AR882 in Patients with Gout, Including Those with Tophaceous Gout


San Diego, California, USA – On December 18, 2024, Arthrosi Therapeutics, Inc. ("Arthrosi") invested and incubated by VBI, is a late-stage biotechnology company developing potentially best-in-class, highly selective next generation URAT1 inhibitors to reduce serum urate levels, flares and tophi in patients with gout. The company announced that it has enrolled more than 50% of patients in its pivotal Phase 3 REDUCE 2 trial evaluating AR882 for the reduction of sUA in gout patients.


Full Circles Therapeutics Achieves Breakthrough in Non-Viral Immune Cell Engineering


Cambridge, Massachusetts – On December 12, 2024, Full Circles Therapeutics ("Full Circles"), a leader in next-generation cell and gene therapies and invested and incubated by VBI. Full Circles announced the publication of a groundbreaking study in Nature Biotechnology. The paper, titled "Efficient Non-Viral Immune Cell Engineering Using Circular Single-Stranded DNA-Mediated Genomic Integration," introduces a novel method for the precise, non-viral engineering of immune cells, which has the potential to enhance both the safety and efficacy of cellular therapies while reducing production costs. Full Circles' innovative approach overcomes these limitations by utilizing circular single-stranded DNA (cssDNA), enabling stable genomic integration without the risks associated with viral delivery systems.

 

About Technoderma Medicines
Technoderma Medicines, Inc. is a privately held clinical stage biopharmaceutical company located in Chengdu Tianfu BioPark, Sichuan, China. Its current core programs focus on development of innovative therapies for Androgenetic Alopecia, Atopic Dermatitis, Psoriasis, Lupus Erythematosus, and scar prevention. Its "first-in-class" small molecule thyromimetic drug candidate TDM-105795 for Androgenetic Alopecia successfully completed Phase 2a clinical testing and is further advancing in development. Technoderma's novel JAK1/TYK2 inhibitor TDM-180935 for Atopic Dermatitis has now demonstrated a favorable safety profile and positive Proof-of-Concept in Ph2a testing. The Company expects to bring a novel oral drug program into Phase 1 clinical testing for other inflammatory skin diseases soon in 2025.  The pipeline targets dermatologic indications.


About VivaVision Biotech 
Established in August 2016, VivaVision biotech is an innovative pharmaceutical company. Since its establishment, the company has focused on the research and development of international leading innovative drugs for the treatment of ophthalmic diseases, and is committed to providing better and better treatment schemes for millions of patients with ophthalmic diseases. The company has an international first-class ophthalmic team, and has established a leading product R&D pipeline. The company’s pipeline product VVN001, VVN539, VVN461 are currently in clinical stage, and other ocular surface and fundus treatment products are in different stages of development. Since its establishment, it has become one of the most leading ophthalmic innovative drug research and development companies in China.


About Arthrosi
Arthrosi Therapeutics, Inc., headquartered in San Diego, CA, is focused on developing AR882, a potentially best-in-class, highly potent and selective next generation URAT1 inhibitor to reduce serum urate levels, flares and tophi in patients with gout. Gout remains a large and growing market with ~ 13M patients in the U.S. alone, ~2M of which have tophaceous gout. AR882 has demonstrated encouraging efficacy and safety compared to SOC in Phase 2 studies as well as impressive results in achieving complete resolution of tophi in a Phase 2b study. Arthrosi is currently advancing AR882 in a pivotal Phase 3 program.


About Full Circles Therapeutics
Full Circles Therapeutics is a biotechnology company at the forefront of advancing next-generation therapeutic cell engineering for the treatment of cancer, autoimmune diseases, and other serious genetically defined conditions. The Company is pioneering non-viral gene-editing technologies with a focus on C4DNA-mediated genomic integration, enabling the development of safe, efficient, scalable, and affordable cell therapies. Full Circles is committed to overcoming the current limitations of cellular therapies and making life-saving treatments accessible to a broader patient population. Headquartered in Cambridge, MA, Full Circles Therapeutics is transforming the landscape of cellular immunotherapy and gene therapy.

Media contact: vivapr@vivabiotech.com
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