Viva has the largest protein structure research platform in the world, and applies first-class softw are and hardware to determine about 13000 crystal structures every year, with a high success rate and a maximum resolution of 0.7Å. So far, Viva has provided protein and structure biology services to about 1032 pharmaceutical enterprises and biotechnology companies around the world. Its customers include the world's top ten pharmaceutical companies and 41 "Fierce Biotech 15 " the most promising biotechnology companies.
It has integrated automatic equipment such as the setup of crystallization condition screening, crystal optimization, solution preparation, crystal observation and imaging. It can efficiently complete the high-throughput screening of thousands of crystallization conditions by different methods such as hanging drop, sitting drop and batch method in the range of 4℃ to 30℃.
The co-crystal structures of proteins and small molecules complexes are obtained by co-crystalliz ation or soaking method.
It has established long-term and in-depth cooperation with 12 synchrotron facilities around the world, and it can visit three synchrotron radiation facilities in a week and complete the collection of thousands of diffraction data sets.
It uses crystallographic methods to screen its own fragment compound library composed of 960 low molecular weight compounds, which can obtain the information of whether the compound binds and the binding site at the same time. The obtained fragment compounds can be quickly optimized into suitable lead compounds.
Molecular replacement, experimental phasing and direct methods are used to determine the protein crystal structures. With the help of parallel processing of high-performance computing clust er platform, the self-developed automatic software can complete the data processing, structure determination and refinement of thousands of diffraction data sets in a short time.
By analyzing the crystal structures of the complexes formed by proteins and compounds, the detailed atomic interactions between the two can be obtained to guide the optimal development of drug molecules; with the help of computational chemistry analysis, the druggability of drug molecules can be greatly improved in a short time; accurate epitope information can be obtained by analyzing the complex structure formed by antigen and antibody.
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