Fragments screening using crystal soaking is an important method in fragment-based drug discovery. This technology usually requires the resolution of the crystal structure of the drug target protein to be higher than 2.5A. In the experimental process, a single crystal of target protein usually grows first and is soaked in the solution drop with compound for a period, and then the protein crystal will be taken out with cryoprotectant and frozen in liquid nitrogen. Then the protein crystals will be shipped to the synchrotron radiation light sources for data collection. Finally, Structures will be determined by Viva scientists, and reports, structure files, as well as theraw and processed data, will be delivered.
High throughput soaking experiments:
“Hit Discovery”, please contact our team.