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Antibody Engineering
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Antibody HumanizationWorkflow
Case Study
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Antibody Affinity MaturationWorkflow
Directed Affinity Maturation Case 1Improving affinity against Antigen A but not Antigen B (Antigen A and B are from one family)
Antibody Engineering Process of Case 1Enhancing antibody affinity for Antigen A while maintaining low affinity for Antigen B, despite a difference of only one amino acid between the two)
Directed Affinity Maturation Case 2Improving affinity against Antigen C and decreasing affinity against Antigen D （Antigen C and D are from one family）
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Antibody Patent Circumvention
Case Study: Antibody Patent CircumventionGoal: Retain affinity to circumvent antibody patent
Case Study: CADD-BAsed Strategies fOr Antibody Patent Selectivity ModulationGoal: To enhance the binding affinity of the dual-target antibody to antigen A, thereby reducing the affinity discrepancy between the two targets.
Case Study: Wet-LAb Validation oF Antibody Patent CircumventionVerify the affinity of mutants using ELISA and SPR methods.
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