XDC Conjugation and Quality Study - XDC Platform - CRO Services

The Viva XDC Platform is a comprehensive platform created by Viva Biotech. Leveraging extensive expertise in the development of antibody drugs, peptide drugs, and small molecule drugs, it offers clients efficient and high-quality XDC development services.

Core Advantages

Extensive R&D Experience

Having over 10 years of experience and having completed hundreds of XDC-related projects

Providing high-quality peptide synthesis, screening, conjugation, and other peptide drug development services

Experts in linker and payload synthesis and design, offering customized solutions

Proficient in various conjugation reactions including lysine, cysteine conjugation and site-specific conjugation, etc
Integrated Platform Advantages

Driven by AIDD and CADD to support various services, including antibody engineering and affinity maturation

Possessing world's leading protein structure research capabilities, particularly excelling in antigen/antibody structural analysis and epitope mapping

Offering comprehensive in vivo characterization services for various drug candidates, including efficacy evaluation, ADME, PK, PD, safety and ex vivo studies
Comprehensive Testing Technologies

Equipped with multiple mass spectrometers and Biacore systems

Supporting comprehensive XDC quality research and analysis

Providing cytokine detection assays, clinical chemistry, hematology, and biomarker detection, covering diseases such as cancer, autoimmune diseases, inflammatory conditions, and diabetes

Service Contents

XDC Conjugation and Quality Study
XDC Chemistry R&D
XDC Functional Studies

XDC Conjugation and Quality Study

Antibody Peptide Conjugation
Site Specific Conjugation
Antibody Biotin Conjugates
Peptide Drug Conjugation Cases

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XDC Chemistry R&D

XDC Chemistry Capabilities
Payload
Linker

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XDC Functional Studies

Antigen Binding and Immune Effect Testing
Cytotoxicity
Internalization
Payload Release

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Viva XDC Capabilities

Antibody and peptide

Antibody platform

Full human, mouse, rabbit, alpaca and camel antibody discovery, BsAb design

CADD and AI-empowered humanization, affinity maturation and other optimization

Antibody production, quality studies and assays

Peptide and PDC platform

Peptide phage display

Peptide synthesis, humanization and sequence optimization, etc.
Attachment site

Lysine

Cysteine

Specific site

Non-natural amino acid

N-Glycan engineering

Others

C and N termini and the amino acid side chain of peptides
Linkers

Design and synthesis

Cleavable linkers

Based around peptides, glucuronides, disulfides and thioethers, etc.

Non-cleavable linkers

Based around peptide, carbohydrate, thioether and PEG components, etc.

Most popularly used-maleimides and analogues
Payloads

Design and synthesis

Small molecules

ADC

PROTAC

Molecular Glue

Peptides

APC & PDC

Oligonucleotides

AOC & POC

Quantify, Characterization and Functional Studies of ADCs

HPLC analysis

Size-exclusion chromatography

Hydrophobic interaction chromatography

Reverse-phase-HPLC

Ion-exchange chromatography
Mass Spectrometry

HDX-MS

Q-TOF, Qtrap and Triple quadrupole
Surface Plasmon Resonance

Biacore 8K

Biacore S200
Protein Structure Analysis

X-ray Crystallography

CryoEM

HDX-MS

ADC Drug

Antigen Binding Evaluation

Internalization

ADC Drug

Characterization

Epitope ID

Antibody structure

DAR and Drug load distribution

Linker property

Peptide Mapping Analysis

Biophysical Analysis

Others
Antigen Binding Evaluation

Binding Affinity

Cell free

Cell
Internalization

Kinetics

Endosome

Lysosome

Payload Release

Cytotoxicity Assay

Fc-mediated Anti-tumor Effect

Payload Release

MoA of Payload

DNA damage

Mitosis

Cell cycle arrest

Apoptosis

Others
Cytotoxicity Assay

Cytotoxicity to Antigen Positive Cell

Antigen high expression

Int and dim expression of antigen

Bystander effect on antigen negative cell

Cell models

Animal models
Fc-mediated Anti-tumor Effect

ADCC

CDC

ADCP