Antibody Engineering

Antibody/Biologics R&D Services

Hmoe / CRO Services / Antibody/Biologics R&D Services / Antibody Engineering

Antibody Engineering

Antibody Humanization

Workflow

Case Study
Antibody Affinity Maturation

Workflow

Directed Affinity Maturation Case 1

Improving affinity against Antigen A but not Antigen B (Antigen A and B are from one family)

Antibody Engineering Process of Case 1

Enhancing antibody affinity for Antigen A while maintaining low affinity for Antigen B, despite a difference of only one amino acid between the two)

Directed Affinity Maturation Case 2

Improving affinity against Antigen C and decreasing affinity against Antigen D （Antigen C and D are from one family）
Antibody Patent Circumvention

Case Study: Antibody Patent Circumvention

Goal: Retain affinity to circumvent antibody patent

Case Study: CADD-BAsed Strategies fOr Antibody Patent Selectivity Modulation

Goal: To enhance the binding affinity of the dual-target antibody to antigen A, thereby reducing the affinity discrepancy between the two targets.

Case Study: Wet-LAb Validation oF Antibody Patent Circumvention

Verify the affinity of mutants using ELISA and SPR methods.

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Area of Interest

CRO Drug R&D Services

CDMO R&D and Production Services

EFS Investment＆Incubation Business

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