In the ternary system kinetics study, Viva's team accomplished the study by coupling one of the proteins to the chip using the SPR technique. As the PROTAC compound is mixed with the other protein at a specific concentration, it flows through the chip in the mobile phase in an experimental design. Currently, Viva team has successfully completed several PROTAC molecular dynamics research projects.
Cases of PROTAC based on SPR technology are shown:
Proteins will be linked by compound which could binding to both protein A and protein B by A-B-A model