Viva provides global customers with a full range of PROTAC/Molecular Glue drug discovery services using the world's leading Structure-Based Drug Discovery technology. These services cover biology and chemistry, including protein preparation and crystal structure studies, screening of PROTAC/Molecular Glue, kinetic studies, drug metabolism, medicinal chemistry, Bioassay, CADD, and other services.
E3 ligases
Deliveries of target protein - PROTAC-E3 ligase ternary complex structures
At the biochemical level, we use various methods such as TR-FRET, Alphascreen, FP, and SPR to detect the binary binding of PROTAC and target protein or E3 ligase, as well as the ternary binding of target protein-PROTAC-E3 ligase. At the cellular level, we evaluate the degradation ability of PROTAC on the target protein and the specificity of the pathway. Specific experimental systems are developed for specific target proteins and disease areas to validate the cellular function of PROTAC.
“PROTAC Degradation Assays and Ternary Complex Assays”, please contact our team.
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