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Epitope Mapping Platform
Antigen epitopes are the basis of protein antigenicity. Identifying protein antigen epitopes is of great significance for disease diagnosis and prognosis, site-directed modification of protein molecules, the design of non-toxic artificial vaccines, and biopharmaceuticals. Structural analysis of the antigen-antibody complex and the identification of antigen epitopes are of significant importance for improving antibody affinity, enhancing antibody stability, antibody humanization, the design of novel antibodies, and antibody patent protection. This is especially crucial in the field of antibody AI design, where antigen epitope analysis is paramount. In order to meet the needs of different customers and projects, Viva Biotech can also provide methods of antigen-antibody crystallization, hydrogen-deuterium exchange (HDX-MS), and Cryo-EM to analyze antigen epitopes.
The Three Major Epitope Mapping Techniques
| Technology | Resolution | Cost | Time |
|---|---|---|---|
| X-ray Crystallography | ~2 Å | + | 7~14 weeks |
| Cryo-EM | 2.5~4 Å | ++ | 3~4 weeks |
| HDX-MS | Surface region | TBD | 2~4 weeks |
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X-ray Crystallography
Crystal Structure CapabilitiesResources~ 400 ㎡ crystallization lab
HT instruments (NT8, Mosquito, Dragonfly, RockImager)
Collaborate with 13 synchrotron facilities
~1,700 hrs beam time in 2025
Achievements highlight in 2025~ 250 protein targets studies
~ 20,000 datasets collected
~ 16,000 structures refined
Accumulated data (As of Dec 31th, 2025)~ 98,000 structures
~ 850 protein targets
~ 260 PROTAC / molecular glue ternary structures
~ 250 Ab/Ag complex structures
Structure Gallery
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Cryo-EM Single Particle Analysis
We offer integrated workflows featured by fast delivery, high quality and close collaboration across different groups or platforms, from hits to leads and pccs.Case Study
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HDX-MS
The Automated Waters UPLC HDX-MS System50+ projects completed
Two-step flexible experiment strategy
Custom HDX methods
Easy reading reports with publish quality figures