Epitope Mapping Platform

Antibody/Biologics R&D Services

Hmoe / CRO Services / Antibody/Biologics R&D Services / Epitope Mapping Platform

Antigen epitopes are the basis of protein antigenicity. Identifying protein antigen epitopes is of great significance for disease diagnosis and prognosis, site-directed modification of protein molecules, the design of non-toxic artificial vaccines, and biopharmaceuticals. Structural analysis of the antigen-antibody complex and the identification of antigen epitopes are of significant importance for improving antibody affinity, enhancing antibody stability, antibody humanization, the design of novel antibodies, and antibody patent protection. This is especially crucial in the field of antibody AI design, where antigen epitope analysis is paramount. In order to meet the needs of different customers and projects, Viva Biotech can also provide methods of antigen-antibody crystallization, hydrogen-deuterium exchange (HDX-MS), and Cryo-EM to analyze antigen epitopes.

The Three Major Epitope Mapping Techniques

Technology	Resolution	Cost	Time
X-ray Crystallography	~2 Å	+	7~14 weeks
Cryo-EM	2.5-4 Å	++	3~4 weeks
HDX-MS	Surface region	TBD	2-4 weeks

X-ray Crystallography

Crystal Structure Capabilities

Resources

~ 400 m² crystallization lab

HT instruments (NT8, Mosquito, Dragonfly, RockImager)

Collaborate with 13 synchrotron facilities

~1,900 hrs beam time in 2024

Achievements highlight in 2024

~ 260 protein targets studies

~ 21,000 datasets collected

~ 18,000 structures refined

Accumulated data (As of Dec 31th, 2024)

82,000 + structures

~ 800 protein targets

150 + PROTAC / molecular glue ternary structures

~ 130 Ab/Ag complex structures

Structure Gallery
Cryo-EM Single Particle Analysis

We offer integrated workflows featured by fast delivery, high quality and close collaboration across different groups or platforms, from hits to leads and pccs.

Case Study
HDX-MS

The Automated Waters UPLC HDX-MS System

50+ projects completed

Two-step flexible experiment strategy

Custom HDX methods

Easy reading reports with publish quality figures

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CRO Drug R&D Services

CDMO R&D and Production Services

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“Epitope Mapping Platform”, please contact our team.