Intact-MS (Intact protein mass spectrometry) technology is used to determine the exact mass of protein molecules, and it is an ideal method to screen covalent binding compound library. When a compound is covalently bound to the protein, the corresponding molecular weight of the protein molecule will increase under denaturing conditions of the Intact-MS, this protein molecular weight shift indicates covalent binding. The following figure describes Viva covalent compound library screening process.
Covalent Compound Library Screening Process
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