Intact-MS Technology

Discovery Biology Services

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Intact-MS (Intact protein mass spectrometry) technology is used to determine the exact mass of protein molecules, and it is an ideal method to screen covalent binding compound library. When a compound is covalently bound to the protein, the corresponding molecular weight of the protein molecule will increase under denaturing conditions of the Intact-MS, this protein molecular weight shift indicates covalent binding. The following figure describes Viva covalent compound library screening process.

Covalent Compound Library Screening Process

Protein Expression and Purification

Membrane Protein Targeted Discovery Technology

Ultrasonic Crushing, High Pressure Homogenate Crushing

Affinity Chromatography Purification

Ion Exchange Purification

Gel Filtration Purification

Dialysis, Dilution Refolding

SDS-PAGE, WB, MS, SEC-MALS Detection
Structural Biology Services
Hit Discovery

Computer-Aided Drug Design

ASMS Technology

SPR Technology

Crystal Soaking Technology

Intact-MS Technology

HTS Technology
Bioassay
Biomolecular Interaction

ASMS Technology

SPR Technology

HDX-MS

Native-MS

Intact-MS

TSA Technology

X-ray Crystal Structure Analysis of Protein

Single-particle Analysis

Microcrystalline Electron Diffraction
Pharmacokinetics
Product Center

Cell-Lines

Crystal Structures

GPCR-Proteins

Antibody

Protein

For more information about

“Hit Discovery”, please contact our team.