Discovery Biology Services
Hit Discovery

Hit discovery is a key step in the discovery of lead compounds, including the design, establishment and screening of compound libraries. The design process of Viva compound library fully considers the structural diversity, physicochemical characteristics, druggability, and solubility, and is continuously optimized by a team of medicinal chemistry experts, computational chemistry experts and hit discovery experts. In addition, we also have a series of advanced screening technologies, which can screen the Viva compound library and the compound library provided by customers.

Compound Library

Viva compound libraries are established based on many years of experience in novel drug discovery and medicinal chemistry, aided by computational chemistry. The libraries can be divided into the following according to their uses and characteristics:

  1. Viva fragment compound library-1

    · 2500 compounds

    · According to the principle of maximum diversity of structure and scaffold

    · From commercial suppliers and internal synthesis

    · Physicochemical properties: Rule of 3, water solubility, LCMS sensitivity

    · Mainly applied to: ASMS and SPR for non-covalent compound screening

  2. Viva fragment compound library-2

    · 960 compounds

    · According to the principle of maximum diversity of structure and scaffold

    · From commercial suppliers

    · Physicochemical properties: Rule of 3, high water solubility

    · Mainly applied to: Crystal soaking and SPR for non-covalent compound screening

  3. Viva GPCR related compound library

    · 6500 compounds

    · Maximum diversity from 5 million commercial compounds

    · Include allosteric and orthosteric compounds

    · Mainly applied to: ASMS for non-covalent compound screening

  4. Viva large diversity compound library

    · 200,000 compounds

    · Maximum diversity from 5 million commercial compounds

    · A sub-library of 20,000 compounds, representing the structural diversity of the whole library

    · Mainly applied to: ASMS for non-covalent compound screening

    · The 20,000 compound sub-library can also be used for bioassay based HTS

  5. Viva covalent fragment compound library

    · According to the covalent binding principle of cysteine and other amino acids

    · From commercial sources, under construction

    · Mainly applied to: Intact-MS and bioassays for covalent binding screening

     

Screening Technologies
Depending on the type of compound library and the needs of our customers for hit discovery, Viva offers hits discover the following technologies.
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