What expression systems does Viva Biotech offer, and how do I choose the right one?

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Time: 2026-07-11

Source: Viva Biotech

[Abstract]:

We support E. coli, baculovirus/insect cell (Sf9/Hi5/Sf21/S2), and mammalian (HEK293/CHO transient and stable) platforms, as well as Pichia pastoris for select targets. In general, selection depends on the target class:

E. coli (1–2 weeks)
Baculovirus/insect cells (3–4 weeks, including virus generation)
Mammalian HEK293/CHO (2 – 3 weeks)
Pichia (5 – 6 weeks, including transformant screening)

We routinely advise on system choice based on target biology, downstream application (crystallography vs. cryo-EM vs. SPR vs. in vivo), and timeline.

Protein Type	Recommended System
Cytosolic proteins (Small)	E. coli
Cytosolic proteins (Large)	Insect/Mammalian
Enzymes	E. coli /Insect
Kinases	E. coli/Insect
GPCRs	Insect/Mammalian
Antibodies	Mammalian
Secreted proteins	Mammalian
Membrane proteins	Insect/Mammalian
Multi-protein complexes	Insect/Mammalian

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