What if my target is historically difficult to express (membrane proteins, GPCRs, intrinsically disordered regions, multi-protein complexes)?

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Time: 2026-07-14

Source: Viva Biotech

[Abstract]:

Viva Biotech has extensive experience working with challenging protein targets, including insoluble proteins, secreted proteins, membrane proteins, and protein complexes. To maximize the chances of success, we leverage multiple expression platforms—including E. coli, baculovirus-insect cells, mammalian cells, and yeast—and tailor purification strategies based on each protein's characteristics.

Strategies include fusion partner screening, truncation/domain-boundary optimization, insertions, nanobody or antibody fragment co-complexing to improve stability (e.g., for cryo-EM), lipid nanodisc/detergent screening for membrane proteins, and iterative small-scale expression trials before committing to large-scale production.

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