Viva Biotech’s chemistry teams continue to build and improve its chemical technology platforms and to provide all-around chemical services for its global clients and partners.
PROTAC (proteolysis-targeting chimeras) is a protein degradation technology that is increasingly used in the drug discovery projects. With PROTAC’s new mechanism of action and novel molecular design, it is shown to overcome some of the shortcomings of traditional small-molecule inhibitors including high doses, side effects, and drug resistance. It has also made significant progress towards the “undruggable targets” in recent years.
Viva polypeptide platform is supported by a team of experienced chemists. The services include the syntheses of branched and non-branched peptides (50 AA long peptide), cyclic peptides (S-S bond or other cyclic elements), peptide labeling and modifications. The platform’s technologies include solid-phase peptide synthesis and modification, peptide labeling, antibody-drug conjugates chemistry, small-molecule centered polypeptide conjugates, and custom synthesis of the peptide-containing molecules.
Photochemistry technology is an essential part of the synthetic chemistry for the establishments of bioactive small molecules. It is routinely use by Viva’s chemists for the formations of carbon-carbon and carbon-heteroatom bonds in the synthesis of pharmaceutically active molecules. With the help of modern photochemical instrumentations and technologies, synthetic efficiency can be significantly improved.
Viva’s catalytic screening platform conducts high throughput screening of catalytic reaction conditions. The use of glove box facilitates inert atmosphere in the absence of air and moisture. The current screening setup allows fast turnaround of 24 conditions within 24-48 hours. Typical reaction types include Buchwald, Heck, Nigishi, Sonogashiras, Suzuki coupling and photo-catalyzed reactions.
Deuterated small molecules are widely used in the drug discovery projects. The C-D bond is more stable than the C-H bond. And it does not impose significant changes to the original molecule’s structure or biochemical properties. The deuterated compounds are often found to improve the metabolic stabilities. From proprietary deuterated compound synthesis to the large scale preparation of the candidate molecule, Viva’s chemistry teams have helped many clients and collaborators achieve their goals.
Fluorescent labeling is the process of cross-linking fluorescent compounds with biomolecules. It is the molecular basis for visualization and quantitative detection. Viva chemistry and biology teams have closely worked together in this field. A wide variety of fluorescent molecules were developed and successfully applied in many drug discovery projects. The targeted biomolecules include proteins, peptides, antibodies, nucleic acids, bacteria, and yeast.
Due to the unique properties of fluorine atom, selective introduction of fluoro and fluoroalkyl groups into biologically active molecules can dramatically improve their properties, such as lipophilicity, bioavailability, and metabolic stability. The design and synthesis of fluorine-containing compounds have become an important part of the drug discovery process. Viva’s fluorine chemistry platform is supported by chemists with post-graduate education background and work experience in the field of fluorine chemistry. It has successfully helped many projects develop fluorinated molecules.
Macrocyclic compound designs are utilized by many discovery projects to further their chemical structure diversity and to help improve molecular recognitions and pharmacological properties. Viva's chemistry teams have worked with clients and partners to develop proprietary macrocyclic molecules that contributed towards the program’s success.
Nucleotide chemistry is used to develop nucleic acid therapeutics such as antisense oligonucleotides (ASOs), siRNA and miRNA. Viva’s chemistry team is experienced with the synthesis of natural and non-natural nucleotides.