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Cryo-EM Technology Platform

Why choose cryo-EM technology?

Featured by fast structural determination of proteins at near-physiological states and no need to grow crystals, Cryo-EM is playing increasingly important roles in drug discovery. Cryo-EM technology is well suited for targets that are challenging for traditional X-ray crystallography or NMR, such as protein complex, membrane proteins or PROTAC/molecular glue ternary complexes. Fast structure determination of targets at atomic resolution makes cryo-EM a very useful tool for structure-based drug discovery (SBDD).

Why choose Viva's cryo-EM services ?

Have delivered more than 300 Cryo-EM structures in the past few years, half of which are at 3.0 Å or better resolution.
Closely collaborate with the protein preparation group to ensure high quality of protein samples from the very beginning.
Have gained extensive experience on ion channels, GPCR, molecular glue/PROTAC E3 ligase and other protein complexes, and well positioned to take challenges and deliver high-quality structures.
Offer an integrated Cryo-EM workflow featuring fast delivery of high quality results.
Provide comprehensive structure-based drug discovery (SBDD) solutions, from target protein preparation to lead compound optimization.

Service Content

Cryo-EM Single Particle Analysis

Cryo-EM Single Particle Analysis is playing increasing roles in structure-based drug discovery (SBDD). The typical workflow includes sample negative staining, cryo grids preparation and optimization, and high resolution cryo-EM data collection & structural determination.

We' ve delivered 300+ cryo-EM structures so far, 60% of which are PROTAC/Glue complex and membrane proteins. 50% of the structures are at 3.0 Å or better resolution.

All structures shown above have been desensitized to avoid any IP issues.
Cryo-EM Characterization of Nanoparticles

Lipid nanoparticles (LNPs) are designed to encapsulate siRNA, which represent a highly promising category of drug-delivery system. Cryo-EM can be used for characteriations of nanoparticle samples in their near-native states.

Examples
Microcrystal Electron Diffraction（MicroED）

Microcrystal electron diffraction (MicroED) is a powerful technique for high resolution structure determination of small molecules. Microcrystals with a dimension of 100nm to 400nm is too small for routine X-ray crystallography yet good for MicroED. MicroED can determine the atomic resolution (usually better than 1 Å) structures of small molecules within a few days.

Structure-Based Drug Discovery (SBDD)

With its advantages in the field of structure-based drug discovery (SBDD), Viva Biotech provides a full range of preclinical innovative drug R&D services. The cryo-EM platform provides negative staining, cryo grid screening and optimization of frozen samples, high-resolution data collection and processing, model building and analysis services.

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Structural Biology Services

X-ray Crystal Structure Analysis of Protein

Cryo-EM Technology Platform

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