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V-DEL
The V-DEL platform, led by our seasoned DEL experts, showcases high-quality DEL libraries and screening methods with high success rate. This platform integrates with Viva Biotech's comprehensive one-stop drug discovery solution, supported by advanced methodologies such as AIDD/CADD. It further synergizes with SBDD/FBDD and incorporates technologies like ASMS, SPR, X-Ray Crystallography, and Cryo-EM, offering a wide range of services. These include target protein production, customized DEL synthesis, affinity selection, follow-up synthesis, hit confirmation and assay development, medicinal chemistry as well as CDMO services. This holistic approach is designed to expedite the discovery of both FIC and BIC drugs.
High-purity, diverse protein
A top protein R&D platform with efficiency and scale.
Proprietary technologies for membrane protein expression and lipid nanodiscs preparation.
High-grade, differential V-DELs
High-quality V-DELs (>100 billion diversity) with innovative strategies and on-DNA reactions.
Leveraging our med chem engine’s collection of large numbers of un-commercially available building blocks (~26,000)
High-quality, fast delivery
5 weeks from Screening to Validatio
1,500 fume hoods
Supported by Viva Biotech’s med chem engine.
Shortened the timelines for both DEL synthesis and off-DNA re-synthesis.
Well-established confirmation process
Viva is a highly experienced provider of ASMS and SPR validation for DEL hits
Well-proven synergetic and holistic strategy
AIDD/CADD powered
Developed synergistic approaches, such as (DEL+FBDD/SBDD) and (DEL + FEP calculation)
Significantly boosts the success rate of DEL screening and its follow-up investigation.
Access to expertise across the organization
The below is the punch line, suggest to keep it as a whole.While you work with one platform at Viva, our entire team of experts with rich experience spanning nearly 20 platforms (including protein production, ASMS, SPR, X-ray crystallography, Cryo-EM, FBDD, SBDD, medicinal chemistry, ADME-PK, AIDD/CADD, and CDMO) is always accessible.
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V-DEL libraries: High qualityV-DEL libraries: High quality
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DesignGeneric& proprietary DELs such as PROTAC, fragmen, cyclopeptide, and warheadless
Target focused or Customized DEls (co-design with clients)
DELs with more diversified and drug like chem space using:
novel or milder on DNA compatible reactions (on top of >50 routinely implemented);
BBs (from>26,000) & scaffoids (from>5000) recommended/analyzed by Al/ML/cheminformatics
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ValidationBB Validation
Scaffold Synthesis and Validation
Route Optimization
Mini Library Validation
Timeline: 1 month, for brand new customized DELs
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ProductionLigation (strict QC)
Chemistry (strict QC)
HPLC purifications
QC strategies
Gel electrophoresis
LCMS
Parallel single tube production
Parallel small-scale DEL production
qPCR
BBQC
Timeline: 1to 2months
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QCHeavy Metal Residues Analysis
qPCR
NGS Analysis (one of the most stringent standards across the indurstry)
DNA-Compatible reactions/Tool box
>50 Reactions for library construction-
Couplings
Suzuki
Heck
Buchwald
Sonogashira
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Deprotections
De-Boc
De-Alloc
De-Fmoc
NO2 reduction
Ester hydrolysis
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Cyclizations
Click
Tetrazole
Hydantoin
Indole formation
Benzimidazolone
Imidazolidin-2-one
Imidazole formation
Macrocyclic peptide
Pictet-Spengler reaction
Benzimidazole formation
Quinazolinone formation
Groebke-Blackburn-
Bienaymé reaction
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Reactions with amines
SN2
SNAr
Urea formation
Michael addition
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Reactions with aldehyes
Wittig reaction
Oxidative amidation
Reductive amination
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Amine capping
Amidation
Sulfonylation
Urea formation
Reductive amination
Carbamate formation
Functional groups
- Acids
- Amines
- Amino acids
- Fmoc amino acids
- Aldehydes
- Alcohols
- Aryl halides
- Boronates
- Sulfonyl chlorides
- Active aromatic halides
*Total 26000+BBs -
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V-DEL screening: High success rateV-DEL screening: High success rate
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V-DEL powered SBDD/FBDD and SBDD/FBDD powered V-DELDV-DEL powered SBDD/FBDD and SBDD/FBDD powered V-DELD
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Case Study: Unknown Target ScreeningCase Study: Unknown Target Screening
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