Micro-crystal Electron Diffraction

Hmoe / CRO Services / Discovery Biology Services / Structural Biology Services / Micro-crystal Electron Diffraction

MicroED is a powerful technique used to resolve the high-resolution structure of small molecule compounds. Microcrystals are too small to be administered by X-ray crystallography but their diffraction patterns can be collected with an electron beam. The diffraction dataset can be processed by conventional crystallographic programs for a rapid atomic resolution (usually better than 1 Å) structure determination. Large efforts are usually required to make microcrystals grow bigger for the X-ray crystallography method. With less sample requirement and less time consumption, microED serves as an ideal approach to determine the structure and crystal form of chemical compounds.

Examples of results

Protein Expression and Purification

Membrane Protein Targeted Discovery Technology

Ultrasonic Crushing, High Pressure Homogenate Crushing

Affinity Chromatography Purification

Ion Exchange Purification

Gel Filtration Purification

Dialysis, Dilution Refolding

SDS-PAGE, WB, MS, SEC-MALS Detection
Structural Biology Services
Hit Discovery

Computer-Aided Drug Design

ASMS Technology

SPR Technology

Crystal Soaking Technology

Intact-MS Technology

HTS Technology
Bioassay
Biomolecular Interaction

ASMS Technology

SPR Technology

HDX-MS

Native-MS

Intact-MS

TSA Technology

X-ray Crystal Structure Analysis of Protein

Single-particle Analysis

Microcrystalline Electron Diffraction
Pharmacokinetics
Product Center

Cell-Lines

Crystal Structures

GPCR-Proteins

Antibody

Protein

For more information about

“Structural Biology Services”, please contact our team.