PROTAC Services

Viva provides global customers with a full range of PROTAC drug discovery services using the world's leading Structure-Based Drug Discovery technology. These services cover biology and chemistry, including protein preparation and crystal structure studies, high-throughput screening of PROTAC molecules, kinetic studies, drug metabolism, medicinal chemistry, Bioassay, CADD, and other services.

  • 50+
    E3 ligases
  • ~80
    Delivery target protein-PROTAC-E3 ligase ternary complex structures
Protein Preparation and Ternary Architecture Study

Using a highly efficient protein expression system and leading target protein structure research capabilities (X-ray & CryoEM), Viva has successfully researched over 30 E3 ligase structures and delivered about 80 PROTAC-E3 ligase-target protein ternary complex structures. These technological advances greatly assisted customers in the subsequent in-depth optimization of PROTAC molecular structure and mechanism research. In addition, Cryo-Electron Microscopy (cryo-EM), a core technology platform we developed in recent years, serves as an essential technical tool for studying target protein-PROTAC-E3 ligase ternary complex structures. By overcoming a series of technical difficulties and with the accumulation of rich experience, Viva’s cryo-EM platform is able to successfully provide structure determination services.

 

PROTAC Molecular Structure Research Collaboration Case Study:

 

Source:Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.

Source: Chung CW, et, al. Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS Chem Biol. 2020 Sep 18;15(9):2316-2323.

For more information about

Protein Preparation and Ternary Architecture Study”, please contact our team.

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