PROTAC Services

Viva provides global customers with a full range of PROTAC drug discovery services using the world's leading Structure-Based Drug Discovery technology. These services cover biology and chemistry, including protein preparation and crystal structure studies, high-throughput screening of PROTAC molecules, kinetic studies, drug metabolism, medicinal chemistry, Bioassay, CADD, and other services.

  • 50+
    E3 ligases
  • ~80
    Delivery target protein-PROTAC-E3 ligase ternary complex structures
Kinetic Study of PROTAC Ternary Systems

In the ternary system kinetics study, Viva's team accomplished the study by coupling one of the proteins to the chip using the SPR technique. As the PROTAC compound is mixed with the other protein at a specific concentration, it flows through the chip in the mobile phase in an experimental design. Currently, Viva team has successfully completed several PROTAC molecular dynamics research projects.

 

Cases of PROTAC based on SPR technology are shown:

Proteins will be linked by compound which could binding to both protein A and protein B by A-B-A model

For more information about

Kinetic Study of PROTAC Ternary Systems”, please contact our team.

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