home        Services        DMPK
DMPK

Viva biotech has built in vitro ADME and in vivo PK platforms for early DMPK screening, MS focused metabolite ID service, biomarker research, and Radio-isotope labeled DMPK studies. The DMPK team is headed by Dr. Shawn Cheng, a 13 year senior scientist at Abbott Laboratories and an expert in the area of biological screening, mass spectrometry, and its application in drug discovery. Dr. Cheng has dozens of first-authored or co-authored papers in Nature, JACS (8), and PNAS etc.

Viva DMPK services include:

  1.     In Vivo DMPK
    1.     Small and Large Animal PK
      1.     Routes of administration (PO, IV, IP, SC etc.) and sampling
      2.     Several different routes of administration for pain models
    2.     Tissue Distribution
      1.     Radioisotope labeled study – drugs/metabolites
      2.     LCMS based – drugs/metabolites and endogenous metabolites/biomarkers
      3.     Cancer tissue – drug and metabolite/biomarker concentration
    3.     In Vivo Drug Metabolism
      1.     Radioisotope labeled study
      2.     LCMS and NMR analysis
    4.     Biliary Excretion
      1.     Rats and dogs
  1.     In Vitro ADMET
    1.     Liver Microsomal Stability and Clearance
      1.     Human and animal
      2.     LCMS analysis
    2.     Plasma Protein Binding
      1.     Dialysis based
      2.     LCMS analysis
    3.     PAMPA Permeability
      1.     LCMS based
      2.     PGP efflux test available
    4.     Drug Metabolism
      1.     Phase I and II
      2.     Reactive metabolites
      3.     Structural identification – LCMS and NMR
  1.     Expertise -- In Vitro ADMET
    1.     CYP Inhibition
      1.     1A2, 2C9, 2D6, 3A4
    2.     CYP Induction
      1.     1A, 2B6, 3A4
    3.     Transporters
      1.     PGP inhibition/efflux
      2.     Amine transporters
      3.     Amino acid transporters
    4.     hERG Inhibition
      1.     Radioligand binding
  1.     Radio-Isotope Labeled DMPK Studies
    1.     Handles commonly used Isotopes (3H, 14C, 35S, 125I, 32P)
    2.     Capable of radio-labeling of cmpds, peptide/protein
    3.     Capable of in vivo PK/PD studies (including non human primate)
    4.     Binding assays
  2.     MS Expertise for Metabolite ID and Biomarker Research

Our facilities include:

  •     5,000 sq ft in-house animal facility for mice, rats, rabbits, and dogs;
  •     5,000 sq ft animal facility for isotope-labeled DMPK (SINAP);
  •     API 3000 LCMS;
  •      TOF-MS.