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Gene–to-Protein & Gene–to-Structure

Viva is the first of its kind in China and has four years of execution experience of life science CRO services. Viva provides gene-to-Protein and Gene-to-Structure service for 9 of the 10 largest global pharmaceutical companies.

Viva has year-round access to the two premier synchrotron facilities: the Chicago Advanced Photon Source (APS) and the Shanghai Synchrotron Radiation Facility (SSRF). 3000-5000 constructs are made; 200-300 targets and 400-500 structures are determined by Viva every year. Viva stands out from its peers for its unique capability with extraordinary capacity. 

● Molecular Biology

● Protein expression

Expression System:

E.coli: 200-400 L/ week; ≥200-500 mg

Baculoviral system: SF9, SF21, and High V cells; 50-100 L/ week

BacMan system: designed for mammalian cells; 50-100 L/ week; 30 mg/ L

293-6E/PTT system: for mammalian cells; 35 mg /L

Mammalian suspension cell culture,

Adenoviral & lentiviral

● Protein Production

Refolding

Chromatography

● Protein Purification and Identification

AKTA

Mass ID

● Protein Crystallization

Three 18 crystallization rooms

Two 4 crystallization rooms

Co-crystallization with compound

Compound soaking

Sparse matrix screen

Optimization with seeding

● Protein Crystallography

Novel structures

Soaking/co-crystallization

Data collection at APS & SSRF (weekly)

● Structural analysis and SBDD

APS
SSRF